Blood pressure was lower in the AC group during application of head clamp pins and emergence and the AC group required less vasopressors intraoperatively. Temporary episodes of desaturation and hypercapnia occurred more often in the AC group. To assess if AC (asleep-awake-asleep) with dexmedetomidine/ propofol/ fentanyl has acceptable perioperative outcomes compared to general anaesthesia. To analyse the safety and maximal extension of tumour resection with AC in the eloquent brain area. To compare the hospital length of stay, hospital cost, perioperative morbidity, and postoperative outcome between patients undergoing awake glioma surgery vs. Furthermore, to assess the impact of previous surgery and treatment modalities on the outcome.
![eloquent brain areas eloquent brain areas](http://4.bp.blogspot.com/-rAzorAjO4UM/Tj07IPO7HCI/AAAAAAAAAC4/J-eMccHVQQE/s1600/Eloquent.jpg)
![eloquent brain areas eloquent brain areas](https://i1.wp.com/neupsykey.com/wp-content/uploads/2020/05/10-1055-b-006-160136_c055_f001.jpg)
Sample Size of AC patients Main findingsStudyStudy designOuyang 2013 RS (1 centre)Ouyang 2013 RS (1 centre)Pereira 2008 1998?007 To evaluate the safety and GDC-0084 price efficacy of fully AC for the resection of primary supratentorial brain tumours near or in eloquent brain areas. (midline-shift n = 103 + no midline-shift n = 283) There was no correlation between midline shift and postoperative nausea or pain in AC. (benign tumour n = 115 + malignant tumour n = 300) 386 2 groups retrospectively built. AC is safe, practical, and effective during resection of supratentorial lesions of diverse pathological range and location. AC was well tolerated and showed a low rate of complications, with the benefit of maximal tumour excision and a potentially better patient outcome. AC in selected patients is an effective, safe and practical procedure, which is accompanied with a short hospital and ICU length of stay.
![eloquent brain areas eloquent brain areas](https://i1.wp.com/neupsykey.com/wp-content/uploads/2020/05/10-1055-b-006-161163_c002_f002.jpg)
AC patients showed a significantly Nutlin-3a chiral web better neurological outcome, faster discharge times and an uneventful surgery. Implementation of the new anaesthesiological approach was successful, with a low operative morbidity and rate of anaesthesia complications, short surgery time, and well tolerance by the patients. 2 groups (eloquent cortex AC n = 511, non-eloquent cortex AC n = 99) To elucidate the outcomes and potential advantages associated with AC for supratentorial tumour resection, treated by one neurosurgeon. No To analyse the individual anaesthetic management, intraoperative complications and postoperative outcome of patients undergoing AC. The safety and effectiveness of AC in 25 patients should be described. To assess the safety and effectiveness of AC in comparison to GA for lesions close to the eloquent cortex.
![eloquent brain areas eloquent brain areas](https://img.medscapestatic.com/article/776/272/776272-fig13.jpg)
Description of a new anaesthesiological protocol and patient outcomes for the first patients undergoing AC surgery in this institution. AC group showed less PONV and pain postoperatively. AC provides adequate sedation, analgesia and a smooth wake-up during the period of neurological monitoring with stable haemodynamic and acceptable respiratory parameters compared to general anaesthesia. Tumours in eloquent brain areas, otherwise considered as inoperable.